OPTIMIZATION OF RIVASTIGMINE CHITOSAN NANOPARTICLES FOR NEURODEGENERATIVE ALZHEIMER; IN VITRO AND EX VIVO CHARACTERIZATIONS

Objective: In an attempt to optimize the anti-Alzheimer effect, rivastigmine-loaded chitosan nanoparticles were developed in order target of brain through skin permeation. Methods: Rivastigmine-loaded chitosan-tripolyphosphate prepared by modified ionic gelation method using tween 80 surfactants different batches with variable chitosan/cross-linker ratios, desirability factors applied choose optimal Nanocarrier and (F15) was selected. Different rivastigmine concentrations loaded highest encapsulation efficiency formulae chosen for further study evaluated scanning electron microscopy (SEM), transmission (TEM) differential calorimetric (DSC). Further, drug loading, Ex-vivo permeation Nano-gel, kinetic studies carried out addition stability along three months under temperature. Results: Particle size polydispersity index showed average 291.6±7.70 490.6±7.42 d. nm. 0.333±0.04 0.570±0.023 respectively. The spherical shape. Drug 4% w/w entrapment (89.80%) loading (40.81). Ex vivo shows that gel not irritant rat had better than aqueous dispersion also capable releasing a sustained manner, follow diffusion model. Optimum formula F15 physical chemical stable. Conclusion: experimental results suitability coated surfactant as potential carrier brain, providing delivery rivastigmine.